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The acute phase reactant orosomucoid-2 directly promotes rheumatoid inflammation

Exp Mol Med

Cytokines, Vascular Endothelial Growth Factors, and PlGF in Autoimmunity: Insights From Rheumatoid Arthritis to Multiple Sclerosis

Immune Netw

Serum amyloid A expression in liver promotes synovial macrophage activation and chronic arthritis via NFAT5

J Clin Invest

Nuclear receptor coactivator 6 is a critical regulator of NLRP3 inflammasome activation and gouty arthritis

Cell Mol Immunol


Factors associated with the composition of the gut microbiome in patients with established rheumatoid arthritis and its value for predicting treatment responses

Arthritis Res Ther

A single-centre retrospective study of factors affecting steroid-free remission of IgG4-related disease conducted in South Korea: a notable outcome after complete resection

Salivary ultrasonography and histopathologic evaluation of secondary Sjögren's syndrome in rheumatoid arthritis patients

Sci Rep

Identification of MYH9 as a key regulator for synoviocyte migration and invasion through secretome profiling

Ann Rheum Dis

Changes in the cholesterol profile of patients with rheumatoid arthritis treated with biologics or Janus kinase inhibitors

J Rheum Dis


Genetic deficiency of nuclear factor of activated T cells 5 attenuates the development of osteoarthritis in mice

Golden Age of Immunotherapy: Challenges and Opportunities

Can whole spine magnetic resonance imaging predict radiographic progression and inflammatory activity in axial spondyloarthritis?

Joint Bone Spine​

Lipidome profile predictive of disease evolution and activity in rheumatoid arthritis

Experimental & Molecular Medicine

Targeted Immunotherapy for Autoimmune Disease

Chronic kidney disease in Korean patients with lupus nephritis: over a 35-year period at a single center

A Rare Case of Ankylosing Spondylitis Coexisting with Relapsing Polychondritis, Antiphospholipid Syndrome,
and Myelodysplastic Syndrome

Re-evaluation of the prognostic significance of oropharyngeal dysphagia in idiopathic inflammatory myopathies

Dysbiotic but nonpathogenic shift in the fecal mycobiota of patients with rheumatoid arthritis

Time-integrated Cumulative Parameters Predictive of Radiographic Progression of Rheumatoid Arthritis:
Real-world Data From a Prospective Single-center Cohort


Sang Youn Jung, Jung Hee Koh, Ki-Jo Kim, Yong-Wook Park, Hyung-In Yang, Sung Jae Choi, Jisoo Lee, Chan-Bum Choi, Wan-Uk Kim

Arthritis Res Ther

Switching from TNFα inhibitor to tacrolimus as maintenance therapy in rheumatoid arthritis after achieving low disease activity with TNFα inhibitors and methotrexate: 24-week result from a non-randomized, prospective, active-controlled trial                                                                                                                                                        


Jung Hee Koh, Saseong Lee, Hyun-Sook Kim, Kyuheon Lee, Chang Seop Lee, Seung-Ah Yoo, Naeun Lee, Wan-Uk Kim

J Clin Med

Development of Monitoring System for Assessing Rheumatoid Arthritis within 5 Minutes

Using a Drop of Bio-Fluids

Riri Kwon, Bong-Ki Hong, Kang-Gu Lee, Eunbyeol Choi, Laurent Sabbagh, Chul-Soo Cho, Naeun Lee, Wan-Uk Kim

Regulation of tumor growth by leukocyte-specific protein 1 in T cells

J Immunother Cancer

Jin-Sun Kong, Ji-Hwan Park, Seung-Ah Yoo, Ki-Myo Kim, Yeung-Jin Bae, Yune-Jung Park, Chul-Soo Cho, Daehee Hwang, Wan-Uk Kim

Dynamic transcriptome analysis unveils key proresolving factors of chronic inflammatory arthritis

J Clin Invest

Yune-Jung Park, Seung-Ah Yoo, Mingyo Kim, Wan-Uk Kim

The Role of Calcium-Calcineurin-NFAT Signaling Pathway in Health and Autoimmune Diseases

Front Immunol

Ji-Won Kim, Jin-Sun Kong, Saseong Lee, Seung-Ah Yoo, Jung Hee Koh, Jingchun Jin, Wan-Uk Kim

Angiogenic cytokines can reflect the synovitis severity and treatment response to biologics in rheumatoid arthritis

Exp Mol Med


Seung-Ah Yoo, Chul-Soo Cho, Wan-Uk Kim

Journal of Rheumatic Diseases

Distinct Urinary Metabolic Profile in Rheumatoid Arthritis Patients: A Possible Link

between Diet and Arthritis Phenotype

Seung-Ah Yoo, Mingyo Kim, Min-Cheol Kang, Jin-Sun Kong, Ki-Myo Kim, Saseong Lee, Bong-Ki Hong, Gi Heon Jeong, Jinhee Lee, Min-Gyeong Shin, Yeon-Gu Kim, Ivana Apicella, Valeria Cicatiello, Sandro De Falco, Chong-Hyeon Yoon, Chul-Soo Cho, Zae Young Ryoo, Seung-Hyo Lee, Wan-Uk Kim

Placental growth factor regulates the generation of T H 17 cells to link angiogenesis with autoimmunity

Nat Immunol

Naeun Lee, Donghyun Kim, Wan-Uk Kim

Role of NFAT5 in the Immune System and Pathogenesis of Autoimmune Diseases

Front Immunol


Saseong Lee, Jin-Sun Kong, Sungyong You, H. Moo Kwon,Seung-Ah Yoo, Chul-Soo Cho and Wan-Uk Kim

Transcription Factor NFAT5 Promotes Migration and Invasion of Rheumatoid Synoviocytes via Coagulation Factor III and CCL2

J Immunol

Sungyong You, Jung Hee Koh, Lin Leng, Wan-Uk Kim, Richard Bucala

The Tumor-Like Phenotype of Rheumatoid Synovium: Molecular Profiling and Prospects for Precision Medicine

Arthritis Rheumatology


Susanna Choi, Sungyong You, Donghyun Kim, Soo Youn Choi, H. Moo Kwon, Hyun-Sook Kim, Daehee Hwang, Yune-Jung Park, Chul-Soo Cho, Wan-Uk Kim

J Clin Invest

Transcription factor NFAT5 promotes macrophage survival in rheumatoid arthritis  

Daehee Hwang, Wan-Uk Kim 

Rheumatoid arthritis: Modelling cytokine signalling networks

Nat Rev Rheumatol

Koh JH, Kim WU

Dysregulation of gut microbiota and chronic inflammatory disease: from epithelial defense to host immunity

Exp Mol Med

Lee N, Kim WU

Microbiota in T-cell homeostasis and inflammatory diseases

Exp Mol Med

Han EJ, Kim HY, Lee N, Kim NH, Yoo SA, Kwon HM, Jue DM, Park YJ, Cho CS, De TQ, Jeong DY, Lim HJ, Park WK, Lee GH, Cho H, Kim WU

Suppression of NFAT5-mediated Inflammation and Chronic Arthritis by Novel κB-binding Inhibitors


Hong BK, You S, Yoo SA, Park D, Hwang D, Cho CS, Kim WU

MicroRNA-143 and -145 modulate the phenotype of synovial fibroblasts in rheumatoid arthritis

Exp Mol Med


MIF allele-dependent regulation of the MIF coreceptor CD44 and role in rheumatoid arthritis

Proc Natl Acad Sci U S A

Kim D, Kim WU

Editorial: Can Prevotella copri Be a Causative Pathobiont in Rheumatoid Arthritis?

Arthritis Rheumatol

Jung Hee Koh, Michael Joseph Kemna Jan Willem Cohen Tervaert, Wan-Uk Kim

Editorial: Can an Increase in Antineutrophil Cytoplasmic Autoantibody Titer Predict Relapses in Antineutrophil Cytoplasmic Antibody–Associated Vasculitis?

Arthritis Rheumatol

Han EJ, Yoo SA, Kim GM, Hwang D, Cho CS, You S, Kim WU

GREM1 Is a Key Regulator of Synoviocyte Hyperplasia and Invasiveness

J Rheumatol

Park YJ, Yoo SA, Hwang D, Cho CS, Kim WU

Identification of novel urinary biomarkers for assessing disease activity and prognosis of rheumatoid arthritis

Exp Mol Med

Kim D, Yoo SA, Kim WU

Gut microbiota in autoimmunity: potential for clinical applications

Arch Pharm Res

Park YJ, Yoo SA, Kim GR, Cho CS, Kim WU

Urinary interleukin-6 as a predictor of radiographic progression in rheumatoid arthritis: A 3-year evaluation

Sci Rep


Seong-Hye Hwang, Seung-Hyun Jung, Saseong Lee, Susanna Choi, Seung-Ah Yoo, Ji-Hwan Park, Daehee Hwang, Seung Cheol Shim, Laurent Sabbagh, Ki-Jo Kim, Sung Hwan Park, Chul-Soo Cho, Bong-Sung Kim, Lin Leng, Ruth R. Montgomery, Richard Bucala, Yeun-Jun Chung, and Wan-Uk Kim

Leukocyte-specific protein 1 regulates T-cell migration in rheumatoid arthritis

Proc Natl Acad Sci U S A

Seung-Ah Yoo, Ji-Hwan Park, Seong-Hye Hwang, Sang-Min Oh, Saseong Lee, Valeria Cicatiello, Sangchul Rho, Sandro De Falco, Daehee Hwang, Chul-Soo Cho, and Wan-Uk Kim

Placental Growth Factor-1 and -2 Induce Hyperplasia and Invasiveness of Primary Rheumatoid Synoviocytes

J Immunol

Sang-Il Lee and Wan-Uk Kim

Dual effects of tumor necrosis factor α inhibitors on septic arthritis: from a "bad friend" to a "good enemy"

Arthritis Rheumatol

Yune-Jung Park, Min Kyung Chung, Daehee Hwang and Wan-Uk Kim

Proteomics in Rheumatoid Arthritis Research

Immune Network

Ki-Jo Kim, Saseong Lee, Wan-Uk Kim

Applications of systems approaches in the study of rheumatic diseases

Korean J Intern Med

2002 ~ 2014

Seung-Ah Yoo, Sungyong You, Hyung-Ju Yoon, Dong-Ho Kim, Hyun-Sook Kim, Kyungho Lee, Jin Hee Ahn, Daehee Hwang, Amy S. Lee, Ki-Jo Kim, Yune-Jung Park, Chul-Soo Cho, and Wan-Uk Kim

A novel pathogenic role of the ER chaperone GRP78/BiP in rheumatoid arthritis

The Journal of Experimental Medicine

Sungyong You, Seung-Ah Yoo, Susanna Choi, Ji-Young Kim, Su-Jung Park, Jong Dae Ji, Tae-Hwan Kim, Ki-Jo Kim, Chul-Soo Cho, Daehee Hwang, and Wan-Uk Kim

Identification of key regulators for the migration and invasion of rheumatoid synoviocytes through a systems approach

Proceedings of the National Academy of Sciences

Seung-Ah Yoo, Hyung-Ju Yoon, Hyun-Sook Kim, Chi-Bom Chae, Sandro De Falco, Chul-Soo Cho, and Wan-Uk Kim

Role of placenta growth factor and its receptor flt-1 in rheumatoid inflammation: a link between angiogenesis and inflammation

Arthritis Rheum

Hyung-Ju Yoon, Sungyong You, Seung-Ah Yoo, Nam-Hoon Kim, H. Moo Kwon, Chong-Hyeon Yoon, Chul-Soo Cho, Daehee Hwang, and Wan-Uk Kim

NF-AT5 is a critical regulator of inflammatory arthritis

Arthritis Rheum

Jin-Sun Kong, Seung-Ah Yoo, Jung-Wook Kim, Seung-Pil Yang, Chi-Bom Chae,
Valeria Tarallo, Sandro De Falco, Sung-Ho Ryu, Chul-Soo Cho, and Wan-Uk Kim

Anti-neuropilin-1 peptide inhibition of synoviocyte survival, angiogenesis, and experimental arthritis

Arthritis Rheum

Nam-Hoon Kim, Susanna Choi, Eun-Jin Han, Bong-Ki Hong, Soo Youn Choi, H. Moo Kwon, Sue-Yun Hwang, Chul-Soo Cho, and Wan-Uk Kim

The xanthine oxidase-NFAT5 pathway regulates macrophage activation and TLR-induced inflammatory arthritis

European Journal of Immunology

Sungyong You, Chul-Soo Cho, Inyoul Lee, Leroy Hood, Daehee Hwang, Wan-Uk Kim

A systems approach to rheumatoid arthritis

PLoS One

Ki-Jo Kim, Chul-Soo Cho and Wan-Uk Kim

Role of placenta growth factor in cancer and inflammation

Experimental and Molecular Medicine

Min Jueng Kang, Yune-Jung Park, Sungyong You, Seung-Ah Yoo, Susanna Choi, Dong-Ho Kim, Chul-Soo Cho, Eugene C. Yi, Daehee Hwang, and Wan-Uk Kim

Urinary proteome profile predictive of disease activity in rheumatoid arthritis

J Proteome Res

Nam-Hoon Kim, Bong-Ki Hong, Soo Youn Choi, Hyug Moo Kwon, Chul-Soo Cho, Eugene C Yi and Wan-Uk Kim

Reactive oxygen species regulate context-dependent inhibition of NFAT5 target genes

Experimental & Molecular Medicine

Taeyoon Son, Hyung-Ju Yoon, Saseong Lee, Won Seuk Jang, Byungjo Jung, and Wan-Uk Kim

Continuous monitoring of arthritis in animal models using optical imaging modalities

J Biomed Opt

Yune-Jung Park, Seung-Ah Yoo, and Wan-Uk Kim

Role of endoplasmic reticulum stress in rheumatoid arthritis pathogenesis

J Korean Med Sci

Yune-Jung Park, Chul-Soo Cho, Paul Emery, Wan-Uk Kim

LDL Cholesterolemia as a Novel Risk Factor for Radiographic Progression of Rheumatoid Arthritis: A Single-Center Prospective Study

PLoS One

Yune-Jung Park, Seung-Ah Yoo, Susanna Choi, Hee-Soo Yoo, Ho-Sung Yoon, Chul-Soo Cho, Ki-Dong Yoo, and Wan-Uk Kim

Association of polymorphisms modulating low-density lipoprotein cholesterol with susceptibility, severity, and progression of rheumatoid arthritis

J Rheumatol

The APOM polymorphism as a novel risk factor for dyslipidaemia in rheumatoid arthritis: a possible shared link between disease susceptibility and dyslipidaemia

Clinical & Experimental Rheumatology

Susanna Choi, Hang-Rae Kim, Lin Leng, Insoo Kang, William L. Jorgensen, Chul-Soo Cho, Richard Bucala, and Wan-Uk Kim

Role of macrophage migration inhibitory factor in the regulatory T cell response of tumor-bearing mice

J Immunol

Jun-Koo Yi, Hei-Jung Kim, Dong-Hoon Yu, Seo-Jin Park, Mi-Jung Shin, Hyung-Soo Yuh, Ki-Beom Bae, Young-Rae Ji, Na-Ri Kim, Si-Jun Park, Jae-Young Kim, Hyun-Shik Lee, Sang-Gyu Lee, Du Hak Yoon, Byung-Hwa Hyun, Wan-Uk Kim, and Zae-Young Ryoo

Regulation of inflammatory responses and fibroblast-like synoviocyte apoptosis by calcineurin-binding protein 1 in mice with collagen-induced arthritis

Arthritis Rheum

Jin-Sun Kong, Seung-Ah Yoo, Jong-Hoon Kang, Wooree Ko, Sangmin Jeon, Chi-Bom Chae, Chul-Soo Cho, Wan-Uk Kim

Suppression of neovascularization and experimental arthritis by D-form of anti-flt-1 peptide conjugated with mini-PEG(™)


Jin-Sun Kong, Seung-Ah Yoo, Hyun-Sook Kim, Hyun Ah Kim, Kyungmoo Yea, Sung-Ho Ryu, Yeun-Jun Chung, Chul-Soo Cho, and Wan-Uk Kim

Inhibition of synovial hyperplasia, rheumatoid T cell activation, and experimental arthritis in mice by sulforaphane, a naturally occurring isothiocyanate

Arthritis Rheum

Wan-Uk Kim, Antoine Sreih, and Richard Bucala

Toll-like receptors in systemic lupus erythematosus; prospects for therapeutic intervention

Autoimmun Rev

Kim HS, Kim CH, Park YH, Kim Wan-Uk

18Fluorine fluorodeoxyglucose-positron emission tomography/computed tomography in dermatomyositis

Joint Bone Spine

Proinflammatory Role of Vascular Endothelial Growth Factor in the Pathogenesis of Rheumatoid Arthritis: Prospects for Therapeutic Intervention

Mediators Of Inflammation

Calcineurin modulates the catabolic and anabolic activity of chondrocytes and participates in the progression of experimental osteoarthritis

Arthritis Rheum

Soluble Fas ligand inhibits angiogenesis in rheumatoid arthritis

Arthritis Res Ther​

Interaction of vascular endothelial growth factor 165 with neuropilin-1 protects rheumatoid synoviocytes from apoptotic death by regulating Bcl-2 expression and Bax translocation

J Immunol

Serum amyloid A binding to formyl peptide receptor-like 1 induces synovial hyperplasia and angiogenesis

J Immunol​

Calcineurin is expressed and plays a critical role in inflammatory arthritis

J Immunol​

Arginine-Rich Anti-Vascular Endothelial Growth Factor (Anti-VEGF) Hexapeptide Inhibits Collagen-Induced Arthritis and VEGF-Stimulated Productions of TNF-α and IL-6 by Human Monocytes

J Immunol​

T Cell Proliferative Response to Type II Collagen in the Inflammatory Process and Joint Damage in Patients with Rheumatoid Arthritis

J Rheumatol​

Elevated matrix metalloproteinase-9 in patients with systemic sclerosis

Arthritis Res Ther​

Increase of cyclooxygenase-2 expression by interleukin 15 in rheumatoid synoviocytes

J Rheumatol

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